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KMID : 0880220140520040350
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Journal of Microbiology
2014 Volume.52 No. 4 p.350 ~ p.353
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Identification of Secreted Virulence Factors of Chromobacterium violaceum
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Thiago Castro-Gomes
Mariana S. Cardoso
Wanderson D. DaRocha
Leticia A. Laibida
Andrea M. A. Nascimento
Luciana W. Zuccherato
Maria Fatima Horta
Marcelo P. Bemquerer
Santuza M. R. Teixeira
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Abstract
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Chromobacterium violaceum, a component of tropical soil microbiota, is an opportunistic pathogenic bacterium that can infect humans and other animals. In addition to identifying a large number of genes that demonstrate the vast biotechnological potential of this bacterium, genome sequencing revealed several virulence factors, including different cytolysins, which can be related to its pathogenicity. Here we confirmed these predictions from genomic analyses by identifying, through mass spectrometry, proteins present in the culture supernatant of C. violaceum that may constitute secreted virulence factors. Among them, we identified a secreted collagenase and the product of a gene with sequence similarity to previously characterized bacterial porins.
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KEYWORD
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Chromobacterium violaceum, genome, hemolysin, virulence factor
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